Within a wide range of concentrations equimolar mixtures of DBcAMP and DBcGMP or of insulin and DBcAMP or of glucagon and DBcGMP faithfully mimicked the mitogenic stimulation of primary neonatal rat hepatocytes. These observations strongly suffest that the intra-cycle growth-promoting effects of the two pancreatic hormones are mediated via both purine cyclic nucleotides in the neonatal rat hepatocytes.
Cyclic AMP and cyclic GMP as the respective mediators of the intracycle stimulation of DNA synthesis and mitosis induced by glucagon and insulin in primary neonatal rat hepatocytes.
ARMATO, Ubaldo;
1981-01-01
Abstract
Within a wide range of concentrations equimolar mixtures of DBcAMP and DBcGMP or of insulin and DBcAMP or of glucagon and DBcGMP faithfully mimicked the mitogenic stimulation of primary neonatal rat hepatocytes. These observations strongly suffest that the intra-cycle growth-promoting effects of the two pancreatic hormones are mediated via both purine cyclic nucleotides in the neonatal rat hepatocytes.
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