Lipodystrophy in patients with HIV-infection has been studied intensively to understand its epidemiology and pathophysiology. Recently its development was attributed to a dysregulation of TNF-α synthesis' homeostasis by HAART. A few years ago it was found that pentoxifylline decreases TNF-α production. We describe one HIV-infected patient, with lipodystrophy syndrome, treated with pentoxifylline without any improvement of lipodystrophic symptoms.
No improvement of lipodystrophy syndrome in an HIV-infected patient.
LANZAFAME, Massimiliano;FAGGIAN, Federica;LATTUADA, Emanuela;ANTOLINI, Dario;CONCIA, Ercole
2004-01-01
Abstract
Lipodystrophy in patients with HIV-infection has been studied intensively to understand its epidemiology and pathophysiology. Recently its development was attributed to a dysregulation of TNF-α synthesis' homeostasis by HAART. A few years ago it was found that pentoxifylline decreases TNF-α production. We describe one HIV-infected patient, with lipodystrophy syndrome, treated with pentoxifylline without any improvement of lipodystrophic symptoms.
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