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|Titolo:||Abnormal expansions of polyclonal large to small size granular lymphocytes: reactive or neoplastic process?|
|Autori interni:||PIZZOLO, Giovanni|
|Data di pubblicazione:||1984|
|Abstract:||Morphological, immunologic, and functional properties of peripheral blood cells from two patients with chronic proliferations of granular lymphocytes are described. Cells from both patients showed a heterogeneous pattern from both a morphological and immunologic standpoint, indicating a polyclonal, rather than a monoclonal, expansion of these cells. In fact, both large and small-to-medium-sized granular lymphocytes were observed, and different percentages of positivity were found in the analysis with a large panel of monoclonal antibodies. Serologic and histologic features support the hypothesis that this lymphocytosis could be secondary to bacterial or viral infections rather than a primary event, suggesting that these patients may have chronic reactive immunoregulatory disorders.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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