Objects. The authors report their experience of gamma knife radiosurgery (GKR) in a large series of pediatric cerebral arteriovenous malformations (cAVMs). The advantages, risks and failures of this approach are presented and discussed. Methods. Gamma knife radiosurgery was performed on 63 children aged le16 years. Haemorrhage was the clinical onset in 50 out of 63 cases. The mean pre-GK cAVM volume was 3.8 cm3. Fifty-eight out of 63 cAVMs were Spetzler-Martin grades I–III. Most lesions (47 out of 63) were in eloquent or deep-seated brain regions. Conclusion. Gamma knife radiosurgery-related complications occurred in 2 out of 47 cases with an available follow-up (1 had transient and 1 permanent morbidity). No bleeding occurred during the latency period. In 39 children with >36-month follow-up, complete cAVM occlusion was angiographically documented in 31, with a 3- and 4-year actuarial obliteration rate of 72 and 77% respectively. High rates of complete obliteration and very low frequency of permanent morbidity with no bleeding during the latency period encourage widespread application of GKR in the treatment of pediatric cAVMs.

Leksell gamma knife radiosurgery for cerebral arteriovenous malformations in pediatric patients

FORONI, Roberto;LUPIDI, Francesco;GEROSA, Massimo;BRICOLO, Albino
2005

Abstract

Objects. The authors report their experience of gamma knife radiosurgery (GKR) in a large series of pediatric cerebral arteriovenous malformations (cAVMs). The advantages, risks and failures of this approach are presented and discussed. Methods. Gamma knife radiosurgery was performed on 63 children aged le16 years. Haemorrhage was the clinical onset in 50 out of 63 cases. The mean pre-GK cAVM volume was 3.8 cm3. Fifty-eight out of 63 cAVMs were Spetzler-Martin grades I–III. Most lesions (47 out of 63) were in eloquent or deep-seated brain regions. Conclusion. Gamma knife radiosurgery-related complications occurred in 2 out of 47 cases with an available follow-up (1 had transient and 1 permanent morbidity). No bleeding occurred during the latency period. In 39 children with >36-month follow-up, complete cAVM occlusion was angiographically documented in 31, with a 3- and 4-year actuarial obliteration rate of 72 and 77% respectively. High rates of complete obliteration and very low frequency of permanent morbidity with no bleeding during the latency period encourage widespread application of GKR in the treatment of pediatric cAVMs.
Brain; Arteriovenous malformations; Children; Radiosurgery; Gamma knife; Prognosis
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/21392
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 35
social impact