In patients with chronic pancreatitis a significant lower clostridia and lactobacilli counts and a higher prevalence of enterobacteria were observed. Moreover, a significant reduction of faecal bacterial deconjugant and lipolytic enzymes and a reduced excretion of LCFAs and FBA were recorded. After treatment with pancreatic enzymes we observed an increase in the number of Clostridia species and a reduction in the enterobacteriaceae species, an increase in hydrolytic enzyme activity, the appearance of bacterial lipase activity, a significant increase in in LCFAs and reversion of FBA to normal.
Effect of pancreatic enzymes administration on intestinal ecosystem in patients with exocrine pancreatic insufficiency. Preliminary results
BOVO, Paolo;BERTAZZONI MINELLI, Elisa;BENINI, Anna;FRULLONI, Luca;CAVALLINI, Giorgio
1997-01-01
Abstract
In patients with chronic pancreatitis a significant lower clostridia and lactobacilli counts and a higher prevalence of enterobacteria were observed. Moreover, a significant reduction of faecal bacterial deconjugant and lipolytic enzymes and a reduced excretion of LCFAs and FBA were recorded. After treatment with pancreatic enzymes we observed an increase in the number of Clostridia species and a reduction in the enterobacteriaceae species, an increase in hydrolytic enzyme activity, the appearance of bacterial lipase activity, a significant increase in in LCFAs and reversion of FBA to normal.
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