Adipose tissue has been used as useful experimental model to assess the effect of hormones counteracting insulin action, such as growth hormone and cortisol. The first step of insulin action at the cellular level, i.e. insulin binding to its receptor on the plasma membrane, has been found to be affected both in rat and human fat cells after 30 minutes' exposure to noradrenaline (NA) 'in vitro'. This effect persisted in rat adipose tissue after 24 hours' preincubation at the initial presence of 3 μM NA. In this report we show a NA effect on insulin binding after a 24 hours exposure to the catecholamine in human adipose tissue.

Long term effect of noradrenaline on insulin binding to human adipose tissue 'in vitro'

ZANCANARO, Carlo;BOSELLO, Ottavio
1986-01-01

Abstract

Adipose tissue has been used as useful experimental model to assess the effect of hormones counteracting insulin action, such as growth hormone and cortisol. The first step of insulin action at the cellular level, i.e. insulin binding to its receptor on the plasma membrane, has been found to be affected both in rat and human fat cells after 30 minutes' exposure to noradrenaline (NA) 'in vitro'. This effect persisted in rat adipose tissue after 24 hours' preincubation at the initial presence of 3 μM NA. In this report we show a NA effect on insulin binding after a 24 hours exposure to the catecholamine in human adipose tissue.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1675
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