Protonation and metal ion co-ordination can induce alpha- and gamma-turns respectively, of the linear octapeptide His-(Gly-His)(3)-Gly (His = histidine, Gly = glycine) and in both cases the imidazole groups of appropriately positioned His residues have been shown to be essential in the stabilisation of the folded structure; divalent metal ions exhibit different folding inducing ability of the octapeptide with Ni2+ having the greatest ability at physiological pH.
Titolo: | Metal ion and proton stabilization of turn motif in the synthetic octapeptide L-Histidyl-(Glycyl-L-Histidyl)3-Glycine |
Autori: | |
Data di pubblicazione: | 1997 |
Rivista: | |
Abstract: | Protonation and metal ion co-ordination can induce alpha- and gamma-turns respectively, of the linear octapeptide His-(Gly-His)(3)-Gly (His = histidine, Gly = glycine) and in both cases the imidazole groups of appropriately positioned His residues have been shown to be essential in the stabilisation of the folded structure; divalent metal ions exhibit different folding inducing ability of the octapeptide with Ni2+ having the greatest ability at physiological pH. |
Handle: | http://hdl.handle.net/11562/15633 |
Appare nelle tipologie: | 01.01 Articolo in Rivista |
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