Protonation and metal ion co-ordination can induce alpha- and gamma-turns respectively, of the linear octapeptide His-(Gly-His)(3)-Gly (His = histidine, Gly = glycine) and in both cases the imidazole groups of appropriately positioned His residues have been shown to be essential in the stabilisation of the folded structure; divalent metal ions exhibit different folding inducing ability of the octapeptide with Ni2+ having the greatest ability at physiological pH.

Metal ion and proton stabilization of turn motif in the synthetic octapeptide L-Histidyl-(Glycyl-L-Histidyl)3-Glycine

MOLINARI, Henriette;
1997

Abstract

Protonation and metal ion co-ordination can induce alpha- and gamma-turns respectively, of the linear octapeptide His-(Gly-His)(3)-Gly (His = histidine, Gly = glycine) and in both cases the imidazole groups of appropriately positioned His residues have been shown to be essential in the stabilisation of the folded structure; divalent metal ions exhibit different folding inducing ability of the octapeptide with Ni2+ having the greatest ability at physiological pH.
PROTEIN, PEPTIDES, DESIGN, CONFORMATION, CONSTRUCTION, IMIDAZOLE
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/15633
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