Laboratory medicine should seek interpretation that is more closely connected to health outcomes and individual physiology. But a vision cannot substitute for evidence or current clinical requirements. The challenge is to determine, measurand by measurand, whether an outcome-based interval offers validated additional value beyond population reference intervals, clinical decision limits, and longitudinal patient data. Until that demonstration is made, the term “optimal” should be used cautiously, and the proposed interval should be clearly distinguished from an established clinical targe.
Comments on Gordon's proposal for outcome-based optimal laboratory intervals
Lippi, Giuseppe
In corso di stampa
Abstract
Laboratory medicine should seek interpretation that is more closely connected to health outcomes and individual physiology. But a vision cannot substitute for evidence or current clinical requirements. The challenge is to determine, measurand by measurand, whether an outcome-based interval offers validated additional value beyond population reference intervals, clinical decision limits, and longitudinal patient data. Until that demonstration is made, the term “optimal” should be used cautiously, and the proposed interval should be clearly distinguished from an established clinical targe.
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