A Physical Exercise Intervention, Delivered Through In-Person or Home-Based Programs, in Patients Living With Cancer and Bone Metastases: A Single-Arm, Feasibility Study

Evidence of the feasibility of physical exercise for patients with bone metastases is still scarce. ,is study assessed the feasibility of in-person or home-based exercise programs and explored their e2cacy in patients with bone lesions. Twenty-one patients with bone metastases were invited to participate in an exercise intervention consisting of 12 weeks of in-person or home-based aerobic and resistance training twice a week. ,e primary study endpoint was the feasibility of the program, including recruitment, completion, attendance, adherence, tolerance rates, and safety. Secondary outcomes were physical 4tness and patient-reported parameters. To analyze data descriptive statistics, Student’s t test and Wilcoxon signed-rank test were applied. ,e recruitment rate was 84%, and only one patient withdrew (5%). ,e median program attendance was 93%, and adherence was 85%, with the home-based program showing a higher adherence rate compared to the in-person delivery. Tolerability was 98%, and 13 mild (Grade 1 or 2) adverse events were registered. At postintervention, an increase in functional capacity was observed, while no signi4cant changes in muscle strength,