The observed inverse trend observed between albumin and PT provides a reliable biochemical explanation that the age-related prolongation of PT in the elderly may be a genuine physiological consequence of a gradually decreasing liver function, further strengthening our recommendation to locally evaluate, verify or adopt age-stratified reference intervals for PT, especially in patients older than 80 years, to improve diagnostic specificity in clinical practice.
Albumin decline corroborates physiological prothrombin time prolongation in the elderly
Lippi, Giuseppe
In corso di stampa
Abstract
The observed inverse trend observed between albumin and PT provides a reliable biochemical explanation that the age-related prolongation of PT in the elderly may be a genuine physiological consequence of a gradually decreasing liver function, further strengthening our recommendation to locally evaluate, verify or adopt age-stratified reference intervals for PT, especially in patients older than 80 years, to improve diagnostic specificity in clinical practice.
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