Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML) are increasingly recognized to exhibit immune dysregulation, which can occasionally present with autoinflammatory manifestations. We describe four patients with MDS/AML harboring p53 mutations and a complex karyotype who developed inflammatory serositis without infectious correlation. All patients showed clinical improvement following corticosteroid therapy.
Serositis as possible manifestation in MDS/AML patients with complex karyotype and TP53 mutation: case series
Gugole, Eleonora;Tamellini, Edoardo;Jance, Sara;Serafin, Nicola;Antonini, Pietro;Colato, Chiara;Krampera, Mauro;Ferrarini, Isacco
;Tanasi, Ilaria
2026-01-01
Abstract
Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML) are increasingly recognized to exhibit immune dysregulation, which can occasionally present with autoinflammatory manifestations. We describe four patients with MDS/AML harboring p53 mutations and a complex karyotype who developed inflammatory serositis without infectious correlation. All patients showed clinical improvement following corticosteroid therapy.
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