This paper illustrates a rare and clinically meaningful con- vergence of systemic sclerosis, extensive medial arterial calcification (MAC), and refractory bilateral osteomyelitis, highlighting the synergistic impact of autoimmune micro- vascular dysfunction and medial calcific vasculopathy on limb ischemia, tissue vulnerability, and infection persis- tence.
Medial arterial calcification and refractory osteomyelitis in systemic sclerosis: a case report and literature review
Presa, FrancescoFormal Analysis
;Villaboni, SimoneInvestigation
;Bonisoli, Giulio LuigiInvestigation
;Friso, SimonettaWriting – Review & Editing
2026-01-01
Abstract
This paper illustrates a rare and clinically meaningful con- vergence of systemic sclerosis, extensive medial arterial calcification (MAC), and refractory bilateral osteomyelitis, highlighting the synergistic impact of autoimmune micro- vascular dysfunction and medial calcific vasculopathy on limb ischemia, tissue vulnerability, and infection persis- tence.
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