Proximal Aorta Flow as a Proxy for Ventricular–Arterial Interaction

Ventricular–arterial coupling (VAC) describes the dynamic interaction between left ventricular (LV) systolic elastance and the time-varying elastance/impedance of the arterial tree, a relationship that governs the instantaneous generation of aortic flow and ultimately cardiac output. VAC, typically expressed as the ratio of effective arterial elastance (Ea) to LV end-systolic elastance (Ees), has provided valuable mechanistic and prognostic insights, but is limited by its lumped, largely steady-state nature and by the need for pressure–volume modeling or complex surrogate formulas. Contemporary time-domain and wave-intensity approaches have underscored that the shape of proximal aortic pressure–flow waveforms encodes rich beat-by-beat information about ventricular–arterial interaction and energy transfer. Doppler echocardiography of the ascending aorta provides a readily available, high-temporal resolution measure of proximal aortic flow that is already used to quantify stroke volume, cardiac output and valvular lesions. We propose that proximal aortic flow, as recorded by Doppler echocardiography, may serve as a clinically practical proxy for beatby-beat VAC, reflecting the instantaneous matching of ventricular and aortic elastances, which regulates the ejected flow towards peripheral tissues according to metabolic needs.