Research on post-COVID syndrome: current gaps and future perspectives

: While it is generally assumed that the outcome of an infectious disease is either recovery or death, post-acute infection syndromes have been long documented, representing a substantial healthcare burden with biological drivers remaining poorly understood. Among post-acute infection sequelae, post-COVID syndrome proved itself to be an elusive condition with complex and dynamic presentation. Over the past three years, multiple cohorts have been created to understand, prevent, and treat post-COVID-19 condition (PCC). Drawing upon the substantial experience gathered during the pandemic, this viewpoint undertakes a rigorous examination of the methodological challenges inherent in current PCC observational research. By analysing "real life" hurdles, we aim to provide clear guidance for future investigations into post-acute infection syndromes and enhance global preparedness for emerging health threats.