A biallelic G/T polymorphism within the first intron of COL1A1 gene at a recognition siter for the transcription factor Sp1 has been shown to be significantly related to bone mass and osteoporotic fractures. We have designed a rapid and efficient genotyping method based on allele-specific polymerase chain reaction (ASPCR)

Rapid and efficient genotype analysis of the COL1A1 Sp1 binding site dimorphism, a genetic marker for bone mineral density

SANGALLI, Antonella;MOTTES, Monica
2002

Abstract

A biallelic G/T polymorphism within the first intron of COL1A1 gene at a recognition siter for the transcription factor Sp1 has been shown to be significantly related to bone mass and osteoporotic fractures. We have designed a rapid and efficient genotyping method based on allele-specific polymerase chain reaction (ASPCR)
COL1A1 gene; polymorphism; osteoporosis
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/11731
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