Robotic Single-Port Versus Robotic Single-Site Hysterectomy in Early Endometrial Cancer: A Case Control Study

Objective To compare surgical outcomes of robotic single-port (RSPH) versus single-site (RSSH) hysterectomy in early-stage endometrial cancer.Methods This is a retrospective case-control study, comparing surgical outcomes of RSPH (Cases) and RSSH (Controls) in early-stage endometrial cancer.Results Twenty-five women who underwent RSPH from June 2024 to November 2024 were matched with 50 historical RSSH controls treated at the same institution by the same surgical team between December 2011 and September 2014. Operation time was similar: 110 min in RSPH and 99 min in RSSH (p = 0.76). Blood loss was 50 mL in RSPH and 60 mL in RSSH (p = 0.14). Hospital stay was shorter in RSSH (3.5 days in RSPH and 3 days in RSSH, p = 0.001).Conclusions Our study confirms the safety and feasibility of RSPH for endometrial cancer without major differences from the RSSH in terms of surgical outcomes.