Endothelial cell aging is strongly associated with mitochondrial dysfunction, particularly the disruption of mitochondrial-nuclear retrograde communication (MNRC), which is essential for sustaining cellular homeostasis and regulating crucial cellular processes. Nanosecond pulsed electric fields (nsPEF) were shown to exert biological effects by targeting mitochondria. However, the nsPEF regulation of MNRC is still unclear.
Nanosecond Pulsed Electric Field Applications Rejuvenate Aging Endnothelial Cells by Rescuing Mitochondrial-to-Nuclear Retrograde Communication.
Meifang Yin;Anna Chiarini;Ubaldo Armato;Ilaria Dal Prà;Jun Wu.
2025-01-01
Abstract
Endothelial cell aging is strongly associated with mitochondrial dysfunction, particularly the disruption of mitochondrial-nuclear retrograde communication (MNRC), which is essential for sustaining cellular homeostasis and regulating crucial cellular processes. Nanosecond pulsed electric fields (nsPEF) were shown to exert biological effects by targeting mitochondria. However, the nsPEF regulation of MNRC is still unclear.
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