This study investigated the neural differentiation potential of adult stem cells derived from skin (SKPs) and adipose tissue (ADSc) from the same donor. When treated with EGF and FGF2, both cell types formed neurospheres that could proliferate and differentiate into glial and neuronal-like cells. These neurospheres were cultured on hyaluronan-based membranes and fibrin-glue scaffolds, showing no chromosomal abnormalities. Cells expressed typical neural markers such as S100, GFAP, nestin, βIII-tubulin, and CNPase. The findings support the potential of these stem cells for neural tissue engineering and the development of an in vitro model to study axonal re-myelination and demyelination mechanisms.
Neural potential of the stem cell population in the adipose and cutaneous tissue
Tussardi, Ilaria Tocco
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2013-01-01
Abstract
This study investigated the neural differentiation potential of adult stem cells derived from skin (SKPs) and adipose tissue (ADSc) from the same donor. When treated with EGF and FGF2, both cell types formed neurospheres that could proliferate and differentiate into glial and neuronal-like cells. These neurospheres were cultured on hyaluronan-based membranes and fibrin-glue scaffolds, showing no chromosomal abnormalities. Cells expressed typical neural markers such as S100, GFAP, nestin, βIII-tubulin, and CNPase. The findings support the potential of these stem cells for neural tissue engineering and the development of an in vitro model to study axonal re-myelination and demyelination mechanisms.
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