The findings of this study indicate that the frequency of side effects following booster vaccination with the Ancestral/BA.4–5 bivalent Pfizer-BioNTech BNT162b2 mRNA vaccine is not significantly associated with baseline humoral immune response except for mild reactions such as chills, injection site reactions and musculoskeletal pain. Based on these results, it may be considered that individuals with higher baseline levels of anti-SARS-CoV-2 IgG antibodies could benefit from prophylactic administration of analgesics, such as acetaminophen, immediately after vaccination. Current evidence suggests that these medications do not seemingly compromise vaccine efficacy, and they may instead help mitigate excessive somatic reactogenicity, thereby enhancing vaccine acceptability.
Correlation between basal humoral immunogenicity and side effects after receiving the bivalent formulation of a mRNA-based vaccine
Pighi, Laura;Salvagno, Gian Luca;Lippi, Giuseppe
In corso di stampa
Abstract
The findings of this study indicate that the frequency of side effects following booster vaccination with the Ancestral/BA.4–5 bivalent Pfizer-BioNTech BNT162b2 mRNA vaccine is not significantly associated with baseline humoral immune response except for mild reactions such as chills, injection site reactions and musculoskeletal pain. Based on these results, it may be considered that individuals with higher baseline levels of anti-SARS-CoV-2 IgG antibodies could benefit from prophylactic administration of analgesics, such as acetaminophen, immediately after vaccination. Current evidence suggests that these medications do not seemingly compromise vaccine efficacy, and they may instead help mitigate excessive somatic reactogenicity, thereby enhancing vaccine acceptability.
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