T-follicular helper (TFH) phenotype can be observed in different lymphoproliferative disorders, including angioimmunoblastic T-cell lymphoma, mycosis fungoides1 primary cutaneous cluster of differentiation (CD)41 small-/medium-sized pleo- morphic lymphoproliferative disorder,2 and Sezary syndrome (SS), apparently without any evidence of prognostic significance.3 The TFH markers expres- sion has been previously reported in SS,4 but to our knowledge, SS with large cell transformation and complete TFH phenotype has never been described.
Sezary syndrome with large cell transformation and T-follicular helper phenotype
Francesco Bellinato;Paola Chiara Rizzo;Pietro Antonini;Paolo Gisondi;Giampiero Girolomoni;
2025-01-01
Abstract
T-follicular helper (TFH) phenotype can be observed in different lymphoproliferative disorders, including angioimmunoblastic T-cell lymphoma, mycosis fungoides1 primary cutaneous cluster of differentiation (CD)41 small-/medium-sized pleo- morphic lymphoproliferative disorder,2 and Sezary syndrome (SS), apparently without any evidence of prognostic significance.3 The TFH markers expres- sion has been previously reported in SS,4 but to our knowledge, SS with large cell transformation and complete TFH phenotype has never been described.
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