Simplified analogues of previously reported NF- κ interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF- κB
Psoralen derivatives as inhibitors of NF-κB/DNA interaction: the critical role of the furan ring
Marzaro, G.;
2015-01-01
Abstract
Simplified analogues of previously reported NF- κ interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF- κBFile in questo prodotto:
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