The invention concerns a method and a new in vitro cell culture system, wherein the cells, preferably isolated from the human central or peripheral nervous system but also from any other human tissue, are incubated on a new conception photo-bioactive hybrid support situated at the interface between the air and the nutrient medium. Such a system allows the cells first to proliferate and then to differentiate and perform functional activities typical of their mature phenotype under optimal aerobic and nourishing conditions. The use of the system for the screening of pharmaceutical, genotoxic and neurotoxic compounds and for in vitro cell culture is also described.
EP3990620B1 - In vitro cell culture system under aerobic conditions suitable for physiological, pathological, pharmacological and toxicological investigations
Chiarini A.;Dal Prà I.;Armato U.
2020-01-01
Abstract
The invention concerns a method and a new in vitro cell culture system, wherein the cells, preferably isolated from the human central or peripheral nervous system but also from any other human tissue, are incubated on a new conception photo-bioactive hybrid support situated at the interface between the air and the nutrient medium. Such a system allows the cells first to proliferate and then to differentiate and perform functional activities typical of their mature phenotype under optimal aerobic and nourishing conditions. The use of the system for the screening of pharmaceutical, genotoxic and neurotoxic compounds and for in vitro cell culture is also described.
| File | Dimensione | Formato | |
|---|---|---|---|
|
EP_3990620_B1 ok.pdf
accesso aperto
Tipologia:
Altro materiale allegato
Licenza:
Dominio pubblico
Dimensione
762.27 kB
Formato
Adobe PDF
|
762.27 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
