We described the emergence of ceftazidime/avibactam and cefiderocol cross -resistance in patients with KPCproducing Klebsiella pneumoniae infections. All strains with ceftazidime/avibactam and cefiderocol crossresistance showed point mutations on KPC CI -loop. Taken together, our results indicate that prolonged exposure to ceftazidime/avibactam can confer cross -resistance to ceftazidime/avibactam and cefiderocol.
In vivo emergence of cefiderocol and ceftazidime/avibactam cross-resistance in KPC-producing Klebsiella pneumoniae following ceftazidime/avibactam -based therapies
Gaibani, Paolo
2024-01-01
Abstract
We described the emergence of ceftazidime/avibactam and cefiderocol cross -resistance in patients with KPCproducing Klebsiella pneumoniae infections. All strains with ceftazidime/avibactam and cefiderocol crossresistance showed point mutations on KPC CI -loop. Taken together, our results indicate that prolonged exposure to ceftazidime/avibactam can confer cross -resistance to ceftazidime/avibactam and cefiderocol.
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