Background: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results: Type I EC was statistically significantly associated with caffeinated (relative risk (RR) - 0.65 for 4+ cups per day vs <= 1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR = 0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kgm(-2) (RR = 0.56; 95% CI: 0.36-0.89).Conclusion: Coffee may protect against Type I EC in obese postmenopausal women.
Intake of coffee, caffeine and other methylxanthines and risk of Type i vs Type II endometrial cancer
Uccella, S.;
2013-01-01
Abstract
Background: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results: Type I EC was statistically significantly associated with caffeinated (relative risk (RR) - 0.65 for 4+ cups per day vs <= 1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR = 0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kgm(-2) (RR = 0.56; 95% CI: 0.36-0.89).Conclusion: Coffee may protect against Type I EC in obese postmenopausal women.
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