Despite their frequency, the pathogenesis for the appear-ance of eruptive cherry angiomas (CAs) has been poorlyinvestigated. In the present cross-sectional study, the roleof age, gender, malignancies, and systemic chronicimmunosuppressive treatments in inducing eruptive CAshas been investigated in 1302 consecutive patients.Advanced age but also tumors, particularly skin tumors,and chronic iatrogenic immunosuppression have beenfound to be associated with eruptive CA occurrence.Among these, chronic immunosuppression resulted in thevariable most strongly associated with eruptive CAs. Thesedata show for the first time the imbalance of skin immunecompetence to be a key predisposing factor for the develop-ment of CAs.CAs represent the most common vascular skin tumors.They occur most commonly in an eruptive form, whichtypically appears at 40–50 years of age and is character-ized by an increase in number and size with time. Lessfrequently, CAs can occur in a paucilesional form, withearlier onset, where only one or a few lesions areobserved; they become stable with time and are probablygenetically determined.1Despite their frequency, the etiology and pathogenesisfor the appearance of CAs have been very poorly investi-gated. Some studies suggested CA induction by chemi-cals,2–4immunosuppression by cyclosporine,5and chronicgraft-versus-host disease.6CAs have been documented tooccur with lymphoproliferative diseases.7,8An involve-ment of specific miRNA has been shown in CA induc-tion.9A possible involvement of human herpesvirus 8 ineruptive CA development, particularly in immunosuppres-sive status, has been found, similar to what has been rec-ognized for major human herpesvirus 8-inducedpathologies.10In spite of these observations, the patho-genesis of CAs is still unclear.The present cross-sectional study was performed withthe aim of assessing, for the first time, a possible role ofthe following factors in inducing eruptive CAs: (i) age;(ii) gender; (iii) malignancies; and (iv) systemic chronicimmunosuppressive treatments.
Predisposing factors for eruptive cherry angiomas: New insights from an observational study
Battaglia, Yuri;
2016-01-01
Abstract
Despite their frequency, the pathogenesis for the appear-ance of eruptive cherry angiomas (CAs) has been poorlyinvestigated. In the present cross-sectional study, the roleof age, gender, malignancies, and systemic chronicimmunosuppressive treatments in inducing eruptive CAshas been investigated in 1302 consecutive patients.Advanced age but also tumors, particularly skin tumors,and chronic iatrogenic immunosuppression have beenfound to be associated with eruptive CA occurrence.Among these, chronic immunosuppression resulted in thevariable most strongly associated with eruptive CAs. Thesedata show for the first time the imbalance of skin immunecompetence to be a key predisposing factor for the develop-ment of CAs.CAs represent the most common vascular skin tumors.They occur most commonly in an eruptive form, whichtypically appears at 40–50 years of age and is character-ized by an increase in number and size with time. Lessfrequently, CAs can occur in a paucilesional form, withearlier onset, where only one or a few lesions areobserved; they become stable with time and are probablygenetically determined.1Despite their frequency, the etiology and pathogenesisfor the appearance of CAs have been very poorly investi-gated. Some studies suggested CA induction by chemi-cals,2–4immunosuppression by cyclosporine,5and chronicgraft-versus-host disease.6CAs have been documented tooccur with lymphoproliferative diseases.7,8An involve-ment of specific miRNA has been shown in CA induc-tion.9A possible involvement of human herpesvirus 8 ineruptive CA development, particularly in immunosuppres-sive status, has been found, similar to what has been rec-ognized for major human herpesvirus 8-inducedpathologies.10In spite of these observations, the patho-genesis of CAs is still unclear.The present cross-sectional study was performed withthe aim of assessing, for the first time, a possible role ofthe following factors in inducing eruptive CAs: (i) age;(ii) gender; (iii) malignancies; and (iv) systemic chronicimmunosuppressive treatments.
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