Primary postpartum haemorrhage (PPH) complicates the postpartum up to 11% of deliveries with different incidences based on geographical regions and is the first cause of maternal deaths, accounting for 25% of cases. Tranexamic acid may play a role in the delicate postpartum balance in case of PPH, inhibiting the conversion of plasminogen to plasmin and reducing the degradation of fibrin. We analyze literature evidence and the possible role of tranexamic acid in clinical practice and future scenarios.
What is the Role of Tranexamic Acid in the Management of Postpartum Haemorrhage? State of Art and Perspectives
Filippo Alberto Ferrari;Simone Garzon;Stefano Uccella;Massimo Franchi
2023-01-01
Abstract
Primary postpartum haemorrhage (PPH) complicates the postpartum up to 11% of deliveries with different incidences based on geographical regions and is the first cause of maternal deaths, accounting for 25% of cases. Tranexamic acid may play a role in the delicate postpartum balance in case of PPH, inhibiting the conversion of plasminogen to plasmin and reducing the degradation of fibrin. We analyze literature evidence and the possible role of tranexamic acid in clinical practice and future scenarios.
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