We measured total anti-SARS-CoV-2 receptor-biding domain (RBD) antibodies in 249 healthcare workers (mean age: 44 ± 13 years; 151 women), who received the first dose of mRNA-based Comirnaty COVID-19 vaccine at different times of the day. Compared with the reference vaccination time point (i.e. <10:00h), vaccine injection at the following times of day elicited a comparable response (all p > 0.05). Under our experimental conditions, we can therefore exclude a possible influence of the timing of primary mRNA-based COVID-19 vaccination on the levels of total anti-SARS-CoV-2 antibodies.

Vaccination time does not influence total anti-SARS-CoV-2 antibodies response

Pighi, Laura;De Nitto, Simone;Salvagno, Gian Luca;Lippi, Giuseppe
2024-01-01

Abstract

We measured total anti-SARS-CoV-2 receptor-biding domain (RBD) antibodies in 249 healthcare workers (mean age: 44 ± 13 years; 151 women), who received the first dose of mRNA-based Comirnaty COVID-19 vaccine at different times of the day. Compared with the reference vaccination time point (i.e. <10:00h), vaccine injection at the following times of day elicited a comparable response (all p > 0.05). Under our experimental conditions, we can therefore exclude a possible influence of the timing of primary mRNA-based COVID-19 vaccination on the levels of total anti-SARS-CoV-2 antibodies.
2024
COVID-19, SARS-CoV-2, Vaccination, antibodies, circadian rhythm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1116266
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