In this work, we propose a comprehensive perspective on genomic instability comprising not only the accumulation of mutations but also telomeric shortening, epigenetic alterations and other mechanisms that could contribute to genomic information conservation or corruption. First, we present mechanisms playing a role in genomic instability across the kingdoms of life. Then, we explore the impact of genomic instability on the human being across its evolutionary history and on present-day human health, with a particular focus on aging and complex disorders. Finally, we discuss the role of non-coding RNAs, highlighting future approaches for a better living and an expanded healthy lifespan.

Genomic instability evolutionary footprints on human health: driving forces or side effects?

Veschetti, Laura;Treccani, Mirko;De Tomi, Elisa;Malerba, Giovanni
2023-01-01

Abstract

In this work, we propose a comprehensive perspective on genomic instability comprising not only the accumulation of mutations but also telomeric shortening, epigenetic alterations and other mechanisms that could contribute to genomic information conservation or corruption. First, we present mechanisms playing a role in genomic instability across the kingdoms of life. Then, we explore the impact of genomic instability on the human being across its evolutionary history and on present-day human health, with a particular focus on aging and complex disorders. Finally, we discuss the role of non-coding RNAs, highlighting future approaches for a better living and an expanded healthy lifespan.
2023
DNA repair
aging
evolutionary genetics
genomic instability
human complex disorder
ncRNA
neurodegenerative diseases
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1100912
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