The results of this retrospective observational study suggest that SARS-CoV-2 IGRA may be a poor predictor of response to bivalent BNT162b2 vaccine in healthy individuals, likely because basal T cell immunity levels are already elevated at baseline due to repeated vaccination and/or natural infection. In contrast, monitoring of total anti-SARS-CoV-2 antibodies remains a better option for this purpose.
Can cellular and humoral immunity predict response to BNT162b2 bivalent booster?
Pighi, Laura;De Nitto, Simone;Salvagno, Gian Luca;Lippi, Giuseppe
2023-01-01
Abstract
The results of this retrospective observational study suggest that SARS-CoV-2 IGRA may be a poor predictor of response to bivalent BNT162b2 vaccine in healthy individuals, likely because basal T cell immunity levels are already elevated at baseline due to repeated vaccination and/or natural infection. In contrast, monitoring of total anti-SARS-CoV-2 antibodies remains a better option for this purpose.
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