Ischemic heart disease (IHD) has been linked with poor brain outcomes. Brain age estimated from structural brain features and its deviation from actual age (brain-age delta in years, positive for accelerated brain aging) can express individual brain health in neurologically intact adults. Prevalent IHD is associated with accelerated brain aging and increased risk of dementia, that is not fully explained by microvascular injury. Besides shared vascular risk factors, additional disease-related mechanisms might contribute to abnormal aging. Brain-age delta may serve as an effective communication tool to illustrate the impact of modifiable risk factors and disease supporting preventative strategies.
ISCHEMIC HEART DISEASE AND VASCULAR RISK FACTORS ARE ASSOCIATED WITH ACCELERATED BRAIN AGING
Ahmed Salih;Ilaria Boscolo Galazzo;Gloria Menegaz;
2023-01-01
Abstract
Ischemic heart disease (IHD) has been linked with poor brain outcomes. Brain age estimated from structural brain features and its deviation from actual age (brain-age delta in years, positive for accelerated brain aging) can express individual brain health in neurologically intact adults. Prevalent IHD is associated with accelerated brain aging and increased risk of dementia, that is not fully explained by microvascular injury. Besides shared vascular risk factors, additional disease-related mechanisms might contribute to abnormal aging. Brain-age delta may serve as an effective communication tool to illustrate the impact of modifiable risk factors and disease supporting preventative strategies.
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