We have planned an infodemiological analysis to establish whether the consumption of some representative NSAIDs has increased all around the world after the spread of COVID-19. We accessed Google Trends using the key words “paracetamol” (or acetaminophen) and “ibuprofen,” setting the geographical location to “worldwide,” and limiting our search to the past 5 years. A highly significant Spearman’s correlation was found between time and weekly Google Trends score of both paracetamol (r = .89; 95% CI, 0.87-0.92; P < .001) and ibuprofen (r = .78; 95% CI, 0.73-0.83; P < .001). Compared to the pre-COVID-19 period, the median (and interquartile range; IQR) weekly Google Trends score significantly increased by 54% for paracetamol (43 with IQR 34-47 vs 28 with IQR 26-31; P < .001) and by 24% for ibuprofen (31 with IQR 27-37 vs 25 with IQR 23-27; P < .001) during the COVID-19 pandemic, with Google Trends score of paracetamol remaining constantly higher than that of Ibuprofen (P < .001). The results of this infodemiological analysis confirm that NSAIDs consumption may have dramatically increased on a worldwide scale after the emergence of the COVID-19 pandemic.

How Much has COVID-19 Contributed to Increase the Worldwide Consumption of Paracetamol and Ibuprofen? Evidence From an Infodemiological Analysis

Mattiuzzi, C;Lippi, G
2023-01-01

Abstract

We have planned an infodemiological analysis to establish whether the consumption of some representative NSAIDs has increased all around the world after the spread of COVID-19. We accessed Google Trends using the key words “paracetamol” (or acetaminophen) and “ibuprofen,” setting the geographical location to “worldwide,” and limiting our search to the past 5 years. A highly significant Spearman’s correlation was found between time and weekly Google Trends score of both paracetamol (r = .89; 95% CI, 0.87-0.92; P < .001) and ibuprofen (r = .78; 95% CI, 0.73-0.83; P < .001). Compared to the pre-COVID-19 period, the median (and interquartile range; IQR) weekly Google Trends score significantly increased by 54% for paracetamol (43 with IQR 34-47 vs 28 with IQR 26-31; P < .001) and by 24% for ibuprofen (31 with IQR 27-37 vs 25 with IQR 23-27; P < .001) during the COVID-19 pandemic, with Google Trends score of paracetamol remaining constantly higher than that of Ibuprofen (P < .001). The results of this infodemiological analysis confirm that NSAIDs consumption may have dramatically increased on a worldwide scale after the emergence of the COVID-19 pandemic.
2023
COVID-19, SARS-CoV-2, Paracetamol, Ibuprofen
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1082169
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