Although it seems at least theoretically agreeable that serological assessment may be useful for defining potential incidence and prevalence of community infections (i.e., “seropositivity”), and thus for driving public health policies, this concept seems no longer so straightforward after the surge of the new Omicron sublineages as it was during the periods of prevalence of the former SARS-CoV-2 variants. This conclusion is based on some important analytical and biological issues that make currently available anti-SARS-CoV-2 commercial immunoassays mostly outdated and poorly harmonized (standardization remains a chimera), and should hence be considered presently unfit for achieving most of the goals for which they have been originally designed and commercialized.
Reliability of SARS-CoV-2 serological testing for influencing public health policies: A reappraisal
Lippi, Giuseppe
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2023-01-01
Abstract
Although it seems at least theoretically agreeable that serological assessment may be useful for defining potential incidence and prevalence of community infections (i.e., “seropositivity”), and thus for driving public health policies, this concept seems no longer so straightforward after the surge of the new Omicron sublineages as it was during the periods of prevalence of the former SARS-CoV-2 variants. This conclusion is based on some important analytical and biological issues that make currently available anti-SARS-CoV-2 commercial immunoassays mostly outdated and poorly harmonized (standardization remains a chimera), and should hence be considered presently unfit for achieving most of the goals for which they have been originally designed and commercialized.
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