The objective was to study complement-mediated cytotoxicity induced by immunoglobulin G (IgG) anti-aquaporin-4 antibodies (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in human serum samples from patients suffering from the rare demyelinating diseases of the CNS neuromyelitis optica spectrum disorder (NMOSD) and MOG-IgG-associated disease (MOGAD).

More efficient complement activation by Anti-Aquaporin-4 compared with Anti-Myelin Oligodendrocyte Glycoprotein antibodies

Mariotto, Sara;Dinoto, Alessandro;
2023

Abstract

The objective was to study complement-mediated cytotoxicity induced by immunoglobulin G (IgG) anti-aquaporin-4 antibodies (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in human serum samples from patients suffering from the rare demyelinating diseases of the CNS neuromyelitis optica spectrum disorder (NMOSD) and MOG-IgG-associated disease (MOGAD).
Humans
Myelin-Oligodendrocyte Glycoprotein
Complement Activation
Immunoglobulin G
Oligodendroglia
Autoantibodies
Aquaporin 4
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1079171
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