The molecular basis of Peripheral T cell lymphoma not otherwise specified (PTCL/ NOS) has remained essentially elusive, due to heterogeneous nature of this malignancy. Recently recurrent genetic lesions affecting normal RNA splicing have been described in different hematological malignancies. Therefore, this study aimed to investigate the possible role of SF3B1 gene, the core component of splicing machinery, in PTCL/NOS pathogenesis.

SF3B1 Gene Abnormalities are Not Common in Peripheral T-Cell Lymphomas-Not Otherwise Specified

Davide Gibellini;
2022

Abstract

The molecular basis of Peripheral T cell lymphoma not otherwise specified (PTCL/ NOS) has remained essentially elusive, due to heterogeneous nature of this malignancy. Recently recurrent genetic lesions affecting normal RNA splicing have been described in different hematological malignancies. Therefore, this study aimed to investigate the possible role of SF3B1 gene, the core component of splicing machinery, in PTCL/NOS pathogenesis.
Peripheral T-Cell Lymphoma not Otherwise Specified; Next Generation Sequencing; SF3B1; RNA-Sequencing; Whole Exome Sequencing; Sanger Sequencing
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1079134
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