The prevalences and distributions of NOSAs appear to be age-independent, with the notable exception of LKM1, which occurs predominately in children. We are, therefore, unable to explain the higher prevalence of SMA (67%) reported by Gregorio et al. [4]. We suppose that the insufficient standardization of the indirect immunofluorescence technique commonly used for NOSA detection may account, at least in part, for this discrepancy; making available reference serum samples for sharing between different laboratories would be an important step to reduce the operator-dependent bias.

Non-organ-specific autoantibodies in children with chronic hepatitis C virus infection [3] (multiple letters)

Davide Gibellini;
2004-01-01

Abstract

The prevalences and distributions of NOSAs appear to be age-independent, with the notable exception of LKM1, which occurs predominately in children. We are, therefore, unable to explain the higher prevalence of SMA (67%) reported by Gregorio et al. [4]. We suppose that the insufficient standardization of the indirect immunofluorescence technique commonly used for NOSA detection may account, at least in part, for this discrepancy; making available reference serum samples for sharing between different laboratories would be an important step to reduce the operator-dependent bias.
NOSA, HCV, autoantibodies
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1078948
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