our study has shown that the presence of serum antibodies reacting with human intracisternal A-type (HIAP) retrovirus proteins is significantly associated with AA. Whether these results indicate the possible involvement of HIAP endogenous retrovirus in the origin and development of AA is still an open question. There is, however, a growing body of evidence suggesting that serum antibodies to endogenous retrovirus proteins might be considered a hallmark of a large array of autoimmune diseases and our findings indicate that AA should also be included in this group of disorders. Increased and concerted research efforts are required to clarify definitively the meaning of anti-endogenous retrovirus protein antibody response in the etiopathogenesis of AA and other autoimmune pathologies.

Serum antibodies against human intracisternal A-type particle (HIAP) endogenous retrovirus in alopecia areata patients: A hallmark of autoimmune disease? [3]

Davide Gibellini;
2004

Abstract

our study has shown that the presence of serum antibodies reacting with human intracisternal A-type (HIAP) retrovirus proteins is significantly associated with AA. Whether these results indicate the possible involvement of HIAP endogenous retrovirus in the origin and development of AA is still an open question. There is, however, a growing body of evidence suggesting that serum antibodies to endogenous retrovirus proteins might be considered a hallmark of a large array of autoimmune diseases and our findings indicate that AA should also be included in this group of disorders. Increased and concerted research efforts are required to clarify definitively the meaning of anti-endogenous retrovirus protein antibody response in the etiopathogenesis of AA and other autoimmune pathologies.
HIAP, retrovirus, alopecia areata
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1078936
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