The updated European Association of Urology (EAU) Guidelines issued a weak recommendation for adjuvant pembrolizumab for patients with high-risk operable clear cell Renal Cell Carcinoma (ccRCC) until final overall survival data are available. High risk of recurrence was defined, as per protocol-criteria, as tumor stage II with nuclear grade 4 or sarcomatoid differentiation, tumor stage III or higher, regional lymph node metastasis, or stage M1 with no evidence of disease. Considering the heterogeneous population included in the recommendation, it has been questioned if adjuvant pembrolizumab may lead to overtreatment of some patients as well as undertreatment of patients with worse prognosis.

Hot topics in renal cancer pathology: implications for clinical management

Caliò, Anna;Marletta, Stefano;
2022

Abstract

The updated European Association of Urology (EAU) Guidelines issued a weak recommendation for adjuvant pembrolizumab for patients with high-risk operable clear cell Renal Cell Carcinoma (ccRCC) until final overall survival data are available. High risk of recurrence was defined, as per protocol-criteria, as tumor stage II with nuclear grade 4 or sarcomatoid differentiation, tumor stage III or higher, regional lymph node metastasis, or stage M1 with no evidence of disease. Considering the heterogeneous population included in the recommendation, it has been questioned if adjuvant pembrolizumab may lead to overtreatment of some patients as well as undertreatment of patients with worse prognosis.
adjuvant therapy; grade; immunotherapy; necrosis; prognosis; renal cell carcinoma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1078366
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