Excess adiposity is associated with several factors involved in carcinogenesis and breast cancer progression. Evidence supporting the role of body composition in breast cancer treatment is promising, but still scanty and mainly focused on adjuvant treatment. The aim of this study was to evaluate the changes in body composition during neoadjuvant chemotherapy and its association with pathologic complete response and survival outcome in patients treated for operable/locally advanced breast cancer.
Predictive and prognostic effect of computed tomography-derived body composition analysis during neoadjuvant chemotherapy for operable and locally advanced breast cancer
Trestini, Ilaria
;Caldart, Alberto;Drudi, Alessandro;Aluffi, Gregorio;Fiorio, Elena;Parolin, Veronica;Zambonin, Valentina;Zanelli, Sara;Tregnago, Daniela;Avancini, Alice;Pilotto, Sara;Aprili, Irene;D'Onofrio, Mirko;Milella, Michele;
2023-01-01
Abstract
Excess adiposity is associated with several factors involved in carcinogenesis and breast cancer progression. Evidence supporting the role of body composition in breast cancer treatment is promising, but still scanty and mainly focused on adjuvant treatment. The aim of this study was to evaluate the changes in body composition during neoadjuvant chemotherapy and its association with pathologic complete response and survival outcome in patients treated for operable/locally advanced breast cancer.
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