Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy-induced peripheral neurotoxicity: systematic review and directions for future research

Background and aims: Chemotherapy-induced peripheral neurotoxicity (CIPN) diagnosis is largely based on patient reported outcomes. Wearables, sensors, and smart devices may potentially provide early detection and monitoring of CIPN. We systematically reviewed data on wearables, sensors, and smart devices to detect and/or monitor signs and symptoms of CIPN. Moreover, we provide directions and recommendations for future studies. Methods: A literature search using PubMed/MEDLINE, Web of Science, IEEE Xplore and CINHAL databases was conducted from database inception until March 2021. The search was further updated in July 2022 to ensure currency of results. Results: 1885 records were title-abstract screened, 33 full texts were assessed, and 16 were included. The retrieved papers were heterogeneous in terms of study design, sample size, CIPN severity, chemotherapy agents, type of wearable/sensor/device applied, parameters of interest and purpose. Interpretation: Data are promising and provide preliminary evidence on wearables, sensors, and smart devices for CIPN detection and monitoring. There are several issues and knowledge gaps that should be addressed. We propose a framework for future studies. This article is protected by copyright. All rights reserved. Keywords: Chemotherapy-induced peripheral neurotoxicity (CIPN); evidence-based medicine; information and communication technology (ICT); sensors; telemedicine.