Objectives: Identification of infection remains a major challenge, particularly in acutely ill patients. The Infection Probability Score (IPS) was developed to help rule out infection in acutely ill patients. In the present study, we determined the IPS in acutely ill, intensive care unit (ICU) patients to assess its use in the diagnosis and treatment of infection.Methods: In this prospective, observational study, we enrolled 107 consecutive patients who were admitted to the ICU without antibiotic therapy. Patients were allocated to four groups according to the probability of infection determined from clinical and microbiological, data and their IPS values were then evaluated daily throughout the ICU stay.Results: The IPS was higher in patients with the highest clinical probability of infection and decreased significantly in these patients after 5 days of effective antimicrobial therapy. The IPS remained below the cut-off value in non-infected patients. Patients in whom inadequate antimicrobial therapy was administered had a greater mortality than the other patients.Conclusions: The IPS had a good predictive value for diagnosis of infection. In addition, dynamic evaluation of this score may help to assess the response to therapy. (c) 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

A prospective evaluation of the Infection Probability Score (IPS) in the intensive care unit

Martini, Alvise;Gottin, Leonardo;
2008

Abstract

Objectives: Identification of infection remains a major challenge, particularly in acutely ill patients. The Infection Probability Score (IPS) was developed to help rule out infection in acutely ill patients. In the present study, we determined the IPS in acutely ill, intensive care unit (ICU) patients to assess its use in the diagnosis and treatment of infection.Methods: In this prospective, observational study, we enrolled 107 consecutive patients who were admitted to the ICU without antibiotic therapy. Patients were allocated to four groups according to the probability of infection determined from clinical and microbiological, data and their IPS values were then evaluated daily throughout the ICU stay.Results: The IPS was higher in patients with the highest clinical probability of infection and decreased significantly in these patients after 5 days of effective antimicrobial therapy. The IPS remained below the cut-off value in non-infected patients. Patients in whom inadequate antimicrobial therapy was administered had a greater mortality than the other patients.Conclusions: The IPS had a good predictive value for diagnosis of infection. In addition, dynamic evaluation of this score may help to assess the response to therapy. (c) 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
infection
antimicrobial therapy
outcome
C-reactive protein
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Body Temperature
C-Reactive Protein
Critical Illness
Cross Infection
Female
Heart Rate
Humans
Leukocyte Count
Male
Middle Aged
Multiple Organ Failure
Intensive Care Units
Severity of Illness Index
File in questo prodotto:
File Dimensione Formato  
IPS journal of infection 2008.pdf

non disponibili

Licenza: Copyright dell'editore
Dimensione 232.87 kB
Formato Adobe PDF
232.87 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1075166
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 16
social impact