Cancer cells hijack tumor-associated macrophages to sustain their outgrowth. In this issue, Mougiakakos and colleagues identify the IKZF1-IRF4/IRF5 axis as a key molecular pathway regulating macrophage polarization in multiple myeloma. These results suggest targeting IKZF1 could provide a new strategy to reprogram myeloma-associated macrophages toward a tumoricidal and immune-activating phenotype.

How to Reprogram Myeloma-Associated Macrophages: Target {IKZF}1

Francesco De Sanctis;Vincenzo Bronte
2021-01-01

Abstract

Cancer cells hijack tumor-associated macrophages to sustain their outgrowth. In this issue, Mougiakakos and colleagues identify the IKZF1-IRF4/IRF5 axis as a key molecular pathway regulating macrophage polarization in multiple myeloma. These results suggest targeting IKZF1 could provide a new strategy to reprogram myeloma-associated macrophages toward a tumoricidal and immune-activating phenotype.
2021
Humans
Ikaros Transcription Factor
Interferon Regulatory Factors
Macrophage Activation
Macrophages
Phenotype
Multiple Myeloma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1074486
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