Since its introduction in 1970s, Sentinel Lymph Node Biopsy (SLNB) has become a standard of care to stage nodal status in melanoma, breast cancer and some gynecological cancers. In 2014 this procedure was incorporated into National Comprehensive Cancer Network (NCCN) guidelines for stage I-II oral squamous cell carcinoma (OSCC) as a reliable alternative to Elective Neck Dissection (END) [1,2]. Recent studies reported that SLNB is still rarely used in patients with OSCC, notwithstanding the fact that SLNB has been shown to be com- parable to END in terms of Overall Survival [1,3–5]. Compared to END, SLNB can provide a significant reduction in post- operative morbidity particularly in OSCC involving subsites such as the floor of the mouth or the ventral surface of tongue, in which en-bloc resection of primary tumor and cervical lymph nodes requires im- mediate reconstruction using flap.

Why SLNB procedure is not currently used in early stage oral squamous cell carcinoma?

Monteleone, F.;Nocini, R.;
2020

Abstract

Since its introduction in 1970s, Sentinel Lymph Node Biopsy (SLNB) has become a standard of care to stage nodal status in melanoma, breast cancer and some gynecological cancers. In 2014 this procedure was incorporated into National Comprehensive Cancer Network (NCCN) guidelines for stage I-II oral squamous cell carcinoma (OSCC) as a reliable alternative to Elective Neck Dissection (END) [1,2]. Recent studies reported that SLNB is still rarely used in patients with OSCC, notwithstanding the fact that SLNB has been shown to be com- parable to END in terms of Overall Survival [1,3–5]. Compared to END, SLNB can provide a significant reduction in post- operative morbidity particularly in OSCC involving subsites such as the floor of the mouth or the ventral surface of tongue, in which en-bloc resection of primary tumor and cervical lymph nodes requires im- mediate reconstruction using flap.
Elective neck dissection; Oral squamous cell carcinoma; Sentinel Lymph Node Biopsy; Technetium-99m-radiolabeled colloid.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1070696
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