We retrospectively analyzed the characteristics of S. aureus bloodstream infections (SA-BSI) from two Italian University hospitals during 2010–2014. A total of 17/337 (5 %) were ICU patients; of these, 16 (94 %) had MRSA-BSI compared with 36 % (116/320) from other wards (P < 0.001). Lower adequate first-line therapy (defined as therapy administered within 48 h of the positive blood culture and effective against a susceptible pathogen) and infectious diseases (ID) specialist consultation were documented in ICU versus non-ICU patients (18 versus 60 % and 53 versus 24 %, P < 0.001 and P = 0.02, respectively)
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