Juvenile Idiopathic Arthritis (JIA) is a paediatric disease of unknown aetiology potentially leading to biomechanical alterations due to local damage of joints. After assessing its reliability, a patient-specific musculoskeletal model of the lower limb was used to investigate the link between joint loading and disease activity in a cohort of JIA children with ankle involvement. We observed a common strategy aiming at protecting the affected ankles with consequent overloading of hip and knee. When quantified at patient specific level, this strategy might allow to identify those cases where a localised steroid injection might not be sufficient to induce remission.

MRI-based musculoskeletal models for the quantification of gait in children with Juvenile Idiopathic Arthritis

Di Marco, Roberto;
2018-01-01

Abstract

Juvenile Idiopathic Arthritis (JIA) is a paediatric disease of unknown aetiology potentially leading to biomechanical alterations due to local damage of joints. After assessing its reliability, a patient-specific musculoskeletal model of the lower limb was used to investigate the link between joint loading and disease activity in a cohort of JIA children with ankle involvement. We observed a common strategy aiming at protecting the affected ankles with consequent overloading of hip and knee. When quantified at patient specific level, this strategy might allow to identify those cases where a localised steroid injection might not be sufficient to induce remission.
Musculoskeletal
Patient-specific
Gait analysis
MRI
Juvenile Idiopathic Arthritis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1061869
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