Several not-yet fully described neutrophil populations exerting either antitumor or suppressive/protumor functions may appear in the circulation of patients with cancer and/or infiltrate tumor tissues. In this issue, Emmons and colleagues provide new information on how complement-dependent "activation" of normal mature neutrophils renders the cells able to inhibit T-cell responsiveness in vitro. The data highlight the complexities of understanding the biology of neutrophil-mediated T-cell suppression.
Characterizing the Complexities of Neutrophils with Suppressive Properties
Cassatella, Marco Antonio
2021-01-01
Abstract
Several not-yet fully described neutrophil populations exerting either antitumor or suppressive/protumor functions may appear in the circulation of patients with cancer and/or infiltrate tumor tissues. In this issue, Emmons and colleagues provide new information on how complement-dependent "activation" of normal mature neutrophils renders the cells able to inhibit T-cell responsiveness in vitro. The data highlight the complexities of understanding the biology of neutrophil-mediated T-cell suppression.
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