Primary eosinophilic gastrointestinal disorders (EGIDs) are a spectrum of emerging inflammatory diseases which may involve any part of the gastrointestinal (GI) tract and lead to a pathological eosinophilic mucosal infiltration.1,2 Based on the anatomical site of the eosinophil inflammation, EGIDs are classified into eosinophilic esophagitis (EoE) and non-esophageal EGIDs. There is increasing interest regarding EGIDs heterogeneity in relation to clinical presentation, comorbidities, natural history, and response to therapies. To date, there are no studies stratifying patients with EGIDs into clinical phenotypes with a data-driven approach. This study aimed to characterize EGID heterogeneity by performing cluster analysis
Cluster analysis of clinical data reveals three pediatric eosinophilic gastrointestinal disorder phenotypes
Giuliana Ferrante;
2022-01-01
Abstract
Primary eosinophilic gastrointestinal disorders (EGIDs) are a spectrum of emerging inflammatory diseases which may involve any part of the gastrointestinal (GI) tract and lead to a pathological eosinophilic mucosal infiltration.1,2 Based on the anatomical site of the eosinophil inflammation, EGIDs are classified into eosinophilic esophagitis (EoE) and non-esophageal EGIDs. There is increasing interest regarding EGIDs heterogeneity in relation to clinical presentation, comorbidities, natural history, and response to therapies. To date, there are no studies stratifying patients with EGIDs into clinical phenotypes with a data-driven approach. This study aimed to characterize EGID heterogeneity by performing cluster analysisI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.