The measurement of anti-SARS-CoV-2 neutralizing antibodies via fully automated, fast, high-throughput, and relatively inexpensive immunoassays is now possible and should thus be widely encouraged before COVID-19 vaccination. Their post-vaccine assessment may also help to solve the dilemma on the optimal dose interval of COVID-19 vaccine administration since the period from the first vaccine dose to the booster could be specifically tailored according to the serum levels of anti-SARS-CoV-2 neutralizing antibodies, while consideration of administering a third dose could be made in older and/or immunocompromised subjects, who often display insufficient serologic response to the administration of the first two doses.
Serological assessment is advisable before COVID-19 vaccination
Lippi, Giuseppe
;
2022-01-01
Abstract
The measurement of anti-SARS-CoV-2 neutralizing antibodies via fully automated, fast, high-throughput, and relatively inexpensive immunoassays is now possible and should thus be widely encouraged before COVID-19 vaccination. Their post-vaccine assessment may also help to solve the dilemma on the optimal dose interval of COVID-19 vaccine administration since the period from the first vaccine dose to the booster could be specifically tailored according to the serum levels of anti-SARS-CoV-2 neutralizing antibodies, while consideration of administering a third dose could be made in older and/or immunocompromised subjects, who often display insufficient serologic response to the administration of the first two doses.
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