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EnglishTaking advantage of the largest consecutive series of patients routinely screened for TKI-resistant mutations by NGS, we here provide a catalog of the most frequent CMs arising in Ph+ leukemias. Our real-life data show that CMs are extremely uncommon in CP-CML, although in 19 patients acquisition of a CM marked the progression to advanced phase. The prevalence of CMs increased to approximately 30% in TKI-resistant AP/BP-CML and Ph+ ALL – consistently with the much greater genetic instability of these settings.
| Titolo: | BCR}-{ABL}1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analyzed by {NGS | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Abstract: | Taking advantage of the largest consecutive series of patients routinely screened for TKI-resistant mutations by NGS, we here provide a catalog of the most frequent CMs arising in Ph+ leukemias. Our real-life data show that CMs are extremely uncommon in CP-CML, although in 19 patients acquisition of a CM marked the progression to advanced phase. The prevalence of CMs increased to approximately 30% in TKI-resistant AP/BP-CML and Ph+ ALL – consistently with the much greater genetic instability of these settings. | |
| Handle: | http://hdl.handle.net/11562/1049484 | |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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