We studied 50 COVID-19 patients (60% males; median age, 50.5 years, interquartile range, 40.5-66.0 years), 32 (64%) requiring hospitalization within 30 days of emergency department (ED visit), 14 (28%) requiring intensive care unit (ICU) admission, and 8 (16%) requiring renal replacement therapy (RRT). The results are shown in Figure 1. Both IL-6*IL-10 and IL-6*IL-8*IL-10 scores displayed similar predictive performance across the outcomes. IL-6*IL-10 displayed the most optimal performance for predicting the primary outcome (ICU admission) with an AUC of 0.89 (95%CI: 0.78 – 0.99).We found an [IL-6]×[IL-10] area under the curve (AUC) of 0.89 for predicting ICU admission, identical to that reported by Nagant et al. Given that [IL-6]×[IL-10] and [IL-6]×[IL-8]×[IL-10] displayed similar predictive performance, we suggest the use of [IL-6]×[IL-10] score, as it requires only 2 variables and is simpler to calculate, as well as more cost-effective. The combined use of IL-6 and IL-10 enables identification of patients with predominant hyperinflammatory response, as well as those who with predominant hypoinflammatory response, both conditions which significantly contribute to development of severe disease.

Combined Cytokine Scores Assessed at Emergency Department Presentation Predicts COVID-19 Critical Illness

Lippi, Giuseppe
2021

Abstract

We studied 50 COVID-19 patients (60% males; median age, 50.5 years, interquartile range, 40.5-66.0 years), 32 (64%) requiring hospitalization within 30 days of emergency department (ED visit), 14 (28%) requiring intensive care unit (ICU) admission, and 8 (16%) requiring renal replacement therapy (RRT). The results are shown in Figure 1. Both IL-6*IL-10 and IL-6*IL-8*IL-10 scores displayed similar predictive performance across the outcomes. IL-6*IL-10 displayed the most optimal performance for predicting the primary outcome (ICU admission) with an AUC of 0.89 (95%CI: 0.78 – 0.99).We found an [IL-6]×[IL-10] area under the curve (AUC) of 0.89 for predicting ICU admission, identical to that reported by Nagant et al. Given that [IL-6]×[IL-10] and [IL-6]×[IL-8]×[IL-10] displayed similar predictive performance, we suggest the use of [IL-6]×[IL-10] score, as it requires only 2 variables and is simpler to calculate, as well as more cost-effective. The combined use of IL-6 and IL-10 enables identification of patients with predominant hyperinflammatory response, as well as those who with predominant hypoinflammatory response, both conditions which significantly contribute to development of severe disease.
Cytokine, Emergency Department, COVID-19
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1048379
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