Complex tumor and immune microenvironment render pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint inhibitors (ICIs). Therefore, a strategy to convert the immune hostile into an immunopermissive tumor is required. Recent studies showed that intratumoral injection of Toll-like receptor 9 agonist IMO-2125 primes the adaptive immune response. Phase I and II trials with intratumoral IMO-2125 demonstrated its safety and antitumoral activity.

Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer

Carbone, Carmine;Piro, Geny;Delfino, Pietro;De Sanctis, Francesco;Ugel, Stefano;Corbo, Vincenzo;Cappello, Paola;Bria, Emilio;Scarpa, Aldo;Tortora, Giampaolo
2021

Abstract

Complex tumor and immune microenvironment render pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint inhibitors (ICIs). Therefore, a strategy to convert the immune hostile into an immunopermissive tumor is required. Recent studies showed that intratumoral injection of Toll-like receptor 9 agonist IMO-2125 primes the adaptive immune response. Phase I and II trials with intratumoral IMO-2125 demonstrated its safety and antitumoral activity.
gastrointestinal neoplasms; immunotherapy; tumor microenvironment
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1048324
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